1027Targeting mitochondrial health in anti-aging: evidence from emblica-derived emblicanin hydrocolloids

Chiung-Man Tsai1**, Chia-Jui Weng2*

1Chest Hospital, Ministry of Health and Welfare, Taiwan
2Department of Food and Beverage Services, Tainan University of Technology, Taiwan

Aging is a critical factor that causes metabolic dysfunctions and anti-aging is therefore a popular issue in regarding to biological and medical industry. How to develop and identify a right subject to fulfill the purpose is therefore a key challenge. This work presents the case of mitochondria–which is the energy source of cells, responsible for the normal operation of energy supply cells. It is very fragile and easy mutation and is an important reason for cell aging. Abnormal mitochondria may lead to the disease of nerves, endocrine, muscle, eyes, etc., causing Parkinson's disease, diabetes, muscle lesions, glaucoma, infertility, arthritis, skin aging, vascular sclerosis and other diseases. The composition for activation of mitochondria can be extracted from many plants. Focus is on anti-aging studies in the following. Growth differentiation factor 11 (GDF11), a member of the transforming growth factor β superfamily of cytokines, was described as an anti-aging factor in two research publications based on the results of a parabiosis mice that were considered as a scientific breakthrough of anti-aging study. The use of emblicanin from emblica extraction in preparing pharmaceutical hydrocolloids for anti-aging includes eating or drinking a composition to increase a concentration of GDF11 in blood. The consumption of emblica extraction hydrocolloids also increases Bioenergetic Healthy Index (BHI) or a concentration of Dehydroepiandrosterone Sulfate (DHEA-S) in blood. According to the results of GDF11 and BHI analysis, embilicanin could be a potential food ingredient of rejuvenation and anti-aging function in human. Related hydrocolloid products are therefore under development which is the key directions of future study.